Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5898226 | 1.00 | SIGMAR1 (0.52) | SIGMAR1EPHX2DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL4796338 | 0.98 | SIGMAR1 (0.51) | SIGMAR1EPHX2DRD2DRD3DRD4 | |
| SCHEMBL11213075 | 0.90 | EPHX2 (0.47) | SIGMAR1EPHX2DRD2DRD3DRD4 | |
| SCHEMBL1792787 | 0.79 | GRIN2B (0.61) | SIGMAR1DRD2DRD3DRD4MTNR1A | |
| SCHEMBL4798922 | 0.78 | EPHX2 (0.56) | SIGMAR1EPHX2DRD2DRD3DRD4 | |
| SCHEMBL4798460 | 0.78 | EPHX2 (0.56) | SIGMAR1EPHX2DRD2DRD3DRD4 | |
| SCHEMBL9675361 | 0.76 | DRD2 (0.44) | SIGMAR1DRD2DRD3DRD4HTR1A | |
| SCHEMBL8569808 | 0.75 | EPHX2 (0.64) | EPHX2MTNR1AMTNR1B | |
| SCHEMBL8569805 | 0.75 | EPHX2 (0.64) | EPHX2MTNR1AMTNR1B | |
| SCHEMBL8569806 | 0.75 | EPHX2 (0.64) | EPHX2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |