Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.54 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.54 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886978 | 1.00 | KDM4E (0.84) | KDM4ELMNAALDH1A1AKR1C3KMT2A | |
| SCHEMBL8887859 | 0.89 | KDM4E (0.67) | KDM4ELMNAALDH1A1AKR1C3APP | |
| SCHEMBL6583474 | 0.89 | APP (0.69) | KDM4ELMNAALDH1A1KMT2AAPP | |
| SCHEMBL8887866 | 0.89 | KDM4E (0.67) | KDM4ELMNAALDH1A1AKR1C3APP | |
| SCHEMBL6583471 | 0.89 | APP (0.69) | KDM4ELMNAALDH1A1KMT2AAPP | |
| SCHEMBL27833553 | 0.85 | KDM4E (0.87) | KDM4ELMNAALDH1A1AKR1C3APP | |
| SCHEMBL5848040 | 0.85 | KDM4E (0.87) | KDM4ELMNAALDH1A1AKR1C3APP | |
| SCHEMBL5848038 | 0.85 | KDM4E (0.87) | KDM4ELMNAALDH1A1AKR1C3APP | |
| SCHEMBL5687918 | 0.83 | LMNA (0.80) | KDM4ELMNAALDH1A1AKR1C3APP | |
| SCHEMBL5687914 | 0.83 | LMNA (0.80) | KDM4ELMNAALDH1A1AKR1C3APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000249-A1 | HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-03 | — | — | WO | disclosed |