Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 4/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | DVL1 | O14640 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27700609 | 0.88 | KDM4E (0.46) | KDM4EHSD17B10ALDH1A1PLK1PLK3 | |
| SCHEMBL4606207 | 0.86 | KDM4E (0.56) | KDM4EHSD17B10PKMLTC4SMETAP2 | |
| SCHEMBL2888623 | 0.85 | KDM4E (0.68) | KDM4EHSD17B10PKMLTC4SMETAP2 | |
| SCHEMBL8886569 | 0.85 | CYP4A11 (0.50) | KDM4EHSD17B10ALDH1A1CYP2C19 | |
| SCHEMBL8533041 | 0.76 | KDM4E (0.69) | KDM4EHSD17B10ALDH1A1POLBCYP2C19 | |
| SCHEMBL31451940 | 0.76 | KDM4E (0.69) | KDM4EHSD17B10ALDH1A1POLBCYP2C19 | |
| SCHEMBL109609 | 0.76 | LCK (0.52) | KDM4EHSD17B10ALDH1A1LCKACMSD | |
| SCHEMBL11803827 | 0.75 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1BRD4 | |
| SCHEMBL7001348 | 0.75 | KDM4E (0.67) | KDM4EHSD17B10METAP2ALDH1A1PLK1 | |
| SCHEMBL664212 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1LCKPOLBACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602277-A | Substituted benzene derivatives useful as neuraminidase inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-02-11 | — | — | US | claimed |
| US-5602277-A | Substituted benzene derivatives useful as neuraminidase inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-02-11 | — | — | US | disclosed |