Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386873 | 0.98 | FLT1 (0.50) | FLT1FLT4KDRALDH1A1MAPT | |
| SCHEMBL31531993 | 0.98 | FLT1 (0.50) | FLT1FLT4KDRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3866369 | 0.96 | FLT1 (0.49) | FLT1FLT4KDRALDH1A1MAPT | |
| SCHEMBL13277970 | 0.96 | FLT1 (0.49) | FLT1FLT4KDRALDH1A1MAPT | |
| SCHEMBL13278275 | 0.86 | LMNA (0.47) | ALDH1A1MAPTCASP6KMT2ACA2 | |
| SCHEMBL4208852 | 0.83 | LMNA (0.48) | ALDH1A1MAPTCASP6KMT2ACA2 | |
| SCHEMBL5936707 | 0.83 | LMNA (0.50) | FLT1FLT4KDRALDH1A1MAPT | |
| SCHEMBL126576 | 0.83 | APEX1 (0.47) | FLT1FLT4KDRALDH1A1MAPT | |
| SCHEMBL2815586 | 0.83 | LMNA (0.59) | ALDH1A1MAPTKMT2AHSD17B10SNCA | |
| SCHEMBL27901125 | 0.82 | HSD17B10 (0.47) | ALDH1A1MAPTCA2HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627285-A | HYPOTENSIVE AGENTS AND TREATMENT OF ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| US-5475016-A | Hypotensive, anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1995-12-12 | — | — | US | disclosed |
| US-5364942-A | Treatment of hypertension and atherosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1994-11-15 | — | — | US | disclosed |
| US-5354749-A | For treating arterial hypertension and atheroschlerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1994-10-11 | — | — | US | disclosed |
| US-5318980-A | Antihypertensive and antiatherosclerotic agents | BAYER AKTIENGESELLSCHAFT (DE) | 1994-06-07 | — | — | US | disclosed |
| US-5254543-A | Hypotensive, anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1993-10-19 | — | — | US | disclosed |