Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967817 | 0.78 | LMNA (0.35) | KDM4EMAPTLMNAMAPK1ALDH1A1 | |
| SCHEMBL8888381 | 0.78 | LMNA (0.44) | KDM4EMAPTLMNANPSR1PPARG | |
| SCHEMBL2406933 | 0.77 | KDM4E (0.43) | KDM4EMAPTLMNANPSR1PPARG | |
| SCHEMBL8888354 | 0.76 | KDM4E (0.50) | KDM4EMAPTLMNANPSR1PPARG | |
| SCHEMBL5405012 | 0.74 | LMNA (0.41) | KDM4EMAPTLMNANPSR1PPARG | |
| SCHEMBL2304762 | 0.69 | MCL1 (0.49) | KDM4EMAPTLMNANPSR1PPARG | |
| SCHEMBL12272917 | 0.69 | FABP3 (0.42) | KDM4EMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL8888390 | 0.69 | MAPT (0.46) | KDM4EMAPTLMNANPSR1PPARG | |
| SCHEMBL21962947 | 0.69 | PTGS1 (0.45) | KDM4EMAPTLMNANPSR1PPARG | |
| SCHEMBL8579254 | 0.69 | SLC9A1 (0.59) | KDM4ESMN1; SMN2SLC9A1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1073988-C | Substituted heteroaromatic acylguanidines, process for their preparation, their use as medicaments and medicaments containing them | HOECHST AG (DE) | 2001-10-31 | — | — | CN | disclosed |
| US-5698581-A | ANTIISCHEMIC AGENTS, ANTIARRHYTHMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-16 | — | — | US | disclosed |
| CN-1117044-A | Substituted heteroaromatic acylguanidines, process for their preparation, their use as medicaments and medicaments containing them | HOECHST AG (DE) | 1996-02-21 | — | — | CN | disclosed |