Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.46 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL8888026 | 1.00 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL28252064 | 0.95 | GRIK1 (0.45) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL5868261 | 0.91 | PMP22 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL5868317 | 0.91 | PMP22 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| D-Aspartate SCHEMBL145539 | 0.89 | — | — | |
| Aspartic Acid SCHEMBL1526976 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL996424 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL11065189 | 0.89 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Aspartic Acid SCHEMBL3230 | 0.89 | — | — | |
| Aspartic Acid SCHEMBL3231 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112912386-A | Cell penetrating peptide based on influenza virus M2 protein | 中国医学科学院基础医学研究所 | 2021-06-04 | — | — | CN | claimed |
| CN-106748841-A | A kind of production method of aspartate methylester | 江苏新汉菱生物工程股份有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-106518701-A | Novel method for synthesizing methyl aspartate | 江苏新汉菱生物工程股份有限公司 | 2017-03-22 | — | — | CN | claimed |
| CN-101684076-B | Process for preparing amides | CHINA PETROCHEMICAL DEV CORP | 2013-04-17 | — | — | CN | claimed |
| CN-102146051-B | Method for separating amide from amino acid ionic liquid | CHINA PETROCHEMICAL DEV CORP | 2013-03-27 | — | — | CN | claimed |
| CN-102039179-B | Catalytic composition for preparing amide and method for preparing amide | CHINA PETROCHEMICAL DEV CORP | 2013-03-06 | — | — | CN | claimed |
| CN-102146051-A | Method for separating amide from amino acid ionic liquid | CHINA PETROCHEMICAL DEV CORP | 2011-08-10 | — | — | CN | claimed |
| CN-102039179-A | Catalytic composition for preparing amide and method for preparing amide | CHINA PETROCHEMICAL DEV CORP | 2011-05-04 | — | — | CN | claimed |
| CN-101684076-A | Process for preparing amides | CHINA PETROCHEMICAL DEV CORP | 2010-03-31 | — | — | CN | claimed |
| CN-106852146-A | Cell penetrating peptides and methods of making and using the same | 塞克洛波特斯公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-106748842-A | A kind of mechanical device for producing aspartate methylester | 江苏新汉菱生物工程股份有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106748841-A | A kind of production method of aspartate methylester | 江苏新汉菱生物工程股份有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106748841-A | A kind of production method of aspartate methylester | 江苏新汉菱生物工程股份有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106518701-A | Novel method for synthesizing methyl aspartate | 江苏新汉菱生物工程股份有限公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-102146051-B | Method for separating amide from amino acid ionic liquid | CHINA PETROCHEMICAL DEV CORP | 2013-03-27 | — | — | CN | disclosed |
| CN-102039179-B | Catalytic composition for preparing amide and method for preparing amide | CHINA PETROCHEMICAL DEV CORP | 2013-03-06 | — | — | CN | disclosed |
| CN-102146051-A | Method for separating amide from amino acid ionic liquid | CHINA PETROCHEMICAL DEV CORP | 2011-08-10 | — | — | CN | disclosed |
| CN-102039179-A | Catalytic composition for preparing amide and method for preparing amide | CHINA PETROCHEMICAL DEV CORP | 2011-05-04 | — | — | CN | disclosed |
| CN-101684076-A | Process for preparing amides | CHINA PETROCHEMICAL DEV CORP | 2010-03-31 | — | — | CN | disclosed |
| US-5688902-A | Process for the preparation of polyimides or of their biodegradable polypeptide hydrolysates | RHONE-POULENC CHIMIE (FR) | 1997-11-18 | — | — | US | disclosed |