Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14315256 | 0.79 | KMT2A (0.51) | MAPTMEN1KMT2AALDH1A1ACHE | |
| SCHEMBL20548781 | 0.77 | MEN1 (0.46) | MAPTMEN1KMT2AALDH1A1MAOB | |
| SCHEMBL621794 | 0.74 | TRPV1 (0.56) | MAPTMEN1KMT2AALDH1A1MAOB | |
| SCHEMBL10936594 | 0.72 | MEN1 (0.63) | MAPTMEN1KMT2AALDH1A1MAOB | |
| SCHEMBL7610342 | 0.72 | AKR1B1 (0.54) | MAPTMEN1KMT2AALDH1A1MAOB | |
| SCHEMBL28094404 | 0.71 | TRPV1 (0.59) | MAPTMEN1KMT2AALDH1A1MAOB | |
| SCHEMBL9182030 | 0.71 | MAPT (0.61) | MAPTMEN1KMT2AALDH1A1AKR1C3 | |
| SCHEMBL13227299 | 0.71 | HTT (0.62) | MAPTMEN1KMT2AALDH1A1MAOA | |
| SCHEMBL4688326 | 0.71 | MAOB (0.53) | MAPTMEN1KMT2AALDH1A1MAOB | |
| SCHEMBL732355 | 0.71 | ALDH1A1 (0.63) | MAPTMEN1KMT2AALDH1A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0665842-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008996-A1 | SULFONAMIDE DERIVATIVES OF BENZENEFUSED HYDROXY SUBSTITUTED CYCLOALKYL AND HETEROCYCLIC RING COMPOUNDS | PFIZER INC. (US) | 1994-04-28 | — | — | WO | disclosed |