Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8887971 | 0.82 | CYP2D6 (0.39) | MEN1KMT2ALMNAKDM4ERAB9A | |
| Bromide SCHEMBL8888561 | 0.80 | KDM4E (0.40) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| Bromide SCHEMBL8888376 | 0.80 | BCHE (0.31) | MEN1KMT2ACYP2C19 | |
| Hydrochloric Acid SCHEMBL8887285 | 0.78 | KDM4E (0.38) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| Bromide SCHEMBL8890436 | 0.77 | KDM1A (0.33) | KDM4EALDH1A1MAPT | |
| SCHEMBL9231688 | 0.75 | KDM1A (0.34) | KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9229544 | 0.74 | ACHE (0.41) | MEN1KMT2ARAB9AALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL1827960 | 0.74 | POLB (0.59) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| SCHEMBL10188095 | 0.73 | POLB (0.61) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G | |
| Bromide SCHEMBL7857771 | 0.71 | MEN1 (0.56) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631264-A | NEUROLOGICAL DISORDERS | SANOFI WINTHROP, INC. (US) | 1997-05-20 | — | — | US | disclosed |