Bromide

Bromide

SCHEMBL7857771

CN(C)c1cccc[n+]1Cc1ccc([N+](=O)[O-])cc1.[Br-]

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 known ✓ P35372 1/20 0.39
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
POLB P06746 2/20 0.56
APOBEC3A P31941 1/20 0.56
APOBEC3G Q9HC16 1/20 0.56
LMNA P02545 2/20 0.53
KDM4E B2RXH2 2/20 0.53
RAB9A P51151 1/20 0.53
L3MBTL1 Q9Y468 2/20 0.49
ALDH1A1 P00352 3/20 0.48
MAPT P10636 4/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
RCE1 Q9Y256 1/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C19 P33261 1/20 0.40
CYP3A4 P08684 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7861856 0.97 MEN1 (0.59) MEN1KMT2APOLBAPOBEC3AAPOBEC3G
Bromide SCHEMBL1827960 0.81 POLB (0.59) MEN1KMT2APOLBAPOBEC3AAPOBEC3G
SCHEMBL10188095 0.80 POLB (0.61) MEN1KMT2APOLBAPOBEC3AAPOBEC3G
Bromide SCHEMBL8664128 0.75 ALDH1A1 (0.60) MEN1KMT2APOLBAPOBEC3AAPOBEC3G
Hydrochloric Acid SCHEMBL7858178 0.75 CHKA (0.44) KDM4EALDH1A1MAPT
SCHEMBL8735025 0.73 MEN1 (0.57) MEN1KMT2APOLBAPOBEC3AAPOBEC3G
Bromide SCHEMBL11163108 0.73 ALDH1A1 (0.53) MEN1KMT2APOLBAPOBEC3AAPOBEC3G
Hydrochloric Acid SCHEMBL7851786 0.72 ACHE (0.46) MEN1KMT2ALMNARAB9AALDH1A1
Bromide SCHEMBL7965212 0.72 MEN1 (0.69) MEN1KMT2APOLBAPOBEC3AAPOBEC3G
Bromide SCHEMBL8889285 0.71 MEN1 (0.51) MEN1KMT2APOLBAPOBEC3AAPOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6204386-B1 PYRIDINIUM COMPOUND ARTEVA NORTH AMERICA S.A.R.L. (CH) 2001-03-20 US claimed
US-6204386-B1 PYRIDINIUM COMPOUND ARTEVA NORTH AMERICA S.A.R.L. (CH) 2001-03-20 US disclosed