Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 6/20 | 0.58 |
| ▸ | APP | P05067 | 5/20 | 0.58 |
| ▸ | BCHE | P06276 | 4/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | UBE2N | P61088 | 1/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.52 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 3/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12390139 | 0.83 | STK17B (0.54) | SIRT5BCHEMAPTNPSR1LMNA | |
| SCHEMBL12390148 | 0.83 | NPSR1 (0.46) | SIRT5BCHEMAPTKMT2ANPSR1 | |
| SCHEMBL8899454 | 0.82 | POLB (0.52) | CASP6BRD4SLC2A1GAA | |
| SCHEMBL30125373 | 0.81 | STK17B (0.62) | APPBCHEKMT2ABRD4MEN1 | |
| SCHEMBL3120956 | 0.79 | CTNNB1 (0.51) | APPKDM4EKMT2ACTNNB1TCF7L2 | |
| SCHEMBL13793556 | 0.78 | BRD4 (0.49) | ACHEAPPBCHERAD52KDM4E | |
| SCHEMBL16280667 | 0.78 | CASP6 (0.92) | ACHEAPPBCHECASP6RAD52 | |
| SCHEMBL13797205 | 0.78 | CTNNB1 (0.68) | CTNNB1TCF7L2 | |
| SCHEMBL30621743 | 0.77 | ACHE (0.49) | ACHEAPPBCHEBRD4SLC2A1 | |
| SCHEMBL3947626 | 0.76 | CTNNB1 (0.48) | ACHEAPPBCHERAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020821-A1 | HETEROARYL DERIVATIVES | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | claimed |
| WO-1997020821-A1 | HETEROARYL DERIVATIVES | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |