Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11878638 | 0.82 | ALDH1A1 (0.44) | DRD2CHEK1CHRM2ADRA2ALMNA | |
| SCHEMBL8249206 | 0.82 | CHEK1 (0.54) | DRD2DRD4HRH4CHEK1OPRK1 | |
| SCHEMBL11634202 | 0.81 | CA12 (0.33) | ALDH1A1CA12CA2CA4CA7 | |
| SCHEMBL27089618 | 0.75 | CHEK1 (0.55) | DRD2DRD4HRH4CHEK1OPRK1 | |
| SCHEMBL11878147 | 0.70 | CHEK1 (0.66) | DRD2DRD4HRH4CHEK1OPRK1 | |
| SCHEMBL8230577 | 0.70 | CHEK1 (0.66) | DRD2DRD4HRH4CHEK1OPRK1 | |
| SCHEMBL11628979 | 0.70 | ALDH1A1 (0.42) | CHEK1ADRA2ALMNAALDH1A1MAPT | |
| SCHEMBL11877192 | 0.69 | CHEK1 (0.51) | CHEK1ALDH1A1HTTCHRM1SMN1; SMN2 | |
| SCHEMBL30935803 | 0.69 | BRPF1 (0.44) | DRD2DRD4HRH4OPRK1CHRM2 | |
| SCHEMBL29485835 | 0.69 | CHEK1 (0.48) | CHEK1LMNAALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000252-A1 | TRICYCLIC INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-01-03 | — | — | WO | disclosed |