Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.55 |
| ▸ | PDE4A | P27815 | 9/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.55 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890532 | 0.87 | PDE4D (0.70) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890076 | 0.84 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8889523 | 0.81 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8900612 | 0.80 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8889534 | 0.80 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890316 | 0.80 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.79 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8898765 | 0.78 | ALOX15 (0.65) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890618 | 0.78 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL2908650 | 0.77 | PDE4D (0.81) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |