Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898765 | 0.92 | ALOX15 (0.65) | PDE4DHSD17B10ALOX15CASP1CASP7 | |
| SCHEMBL8890415 | 0.87 | PDE4D (0.56) | PDE4DHSD17B10ALOX15CASP1CASP7 | |
| SCHEMBL8901131 | 0.80 | MAPT (0.62) | HSD17B10ALOX15CASP1CASP7MAPT | |
| SCHEMBL8889395 | 0.80 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL8898716 | 0.80 | NPC1 (0.60) | HSD17B10MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL8890076 | 0.79 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL8889523 | 0.78 | PDE4D (0.61) | PDE4DHSD17B10MAPTPDE4APDE4B | |
| SCHEMBL8890532 | 0.77 | PDE4D (0.70) | PDE4DMAPTPDE4APDE4BPDE4C | |
| SCHEMBL8889534 | 0.77 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890618 | 0.77 | PDE4D (0.66) | PDE4DHSD17B10MAPTPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |