Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.64 |
| ▸ | PDE4A | P27815 | 14/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.57 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891532 | 0.88 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8888978 | 0.87 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8889824 | 0.86 | PDE4B (0.71) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8889614 | 0.85 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8891152 | 0.85 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8889779 | 0.82 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8889648 | 0.80 | PDE4B (0.74) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890987 | 0.79 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.79 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890369 | 0.78 | PDE4B (0.74) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |