Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.57 |
| ▸ | PDE4A | P27815 | 8/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.57 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888978 | 0.87 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890145 | 0.84 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8889907 | 0.82 | PDE4D (0.64) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8888975 | 0.82 | PDE4D (0.70) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8892872 | 0.80 | KMT2A (0.55) | KMT2AMAPK1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8891532 | 0.80 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8891152 | 0.79 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890162 | 0.79 | KMT2A (0.53) | KMT2AMAPK1MEN1ALDH1A1 | |
| SCHEMBL8891655 | 0.78 | PDE4B (0.70) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8889614 | 0.78 | PDE4D (0.73) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |