Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.67 |
| ▸ | PKM | P14618 | 7/20 | 0.67 |
| ▸ | TP53 | P04637 | 6/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GRM5 | P41594 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890243 | 0.90 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL13117486 | 0.84 | HTT (0.49) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL8901131 | 0.84 | MAPT (0.62) | NPC1RAB9ASMN1; SMN2TP53HSD17B10 | |
| SCHEMBL6451282 | 0.82 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL4345197 | 0.82 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL8890415 | 0.82 | PDE4D (0.56) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL4183752 | 0.81 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL4197833 | 0.81 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL27572517 | 0.81 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL4190662 | 0.79 | SMN1; SMN2 (0.68) | NPC1RAB9ASMN1; SMN2PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |