Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 6/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900612 | 0.87 | PDE4D (0.60) | PDE4DNPC1HSD17B10TP53RAB9A | |
| SCHEMBL8890668 | 0.84 | PDE4D (0.57) | PDE4DNPC1HSD17B10TP53RAB9A | |
| SCHEMBL8898765 | 0.83 | ALOX15 (0.65) | PDE4DNPC1HSD17B10TP53RAB9A | |
| SCHEMBL8890122 | 0.82 | NPC1 (0.67) | NPC1HSD17B10TP53RAB9ASMN1; SMN2 | |
| SCHEMBL8890243 | 0.81 | NPC1 (0.68) | NPC1HSD17B10TP53RAB9ASMN1; SMN2 | |
| SCHEMBL4183752 | 0.77 | NPC1 (0.73) | NPC1HSD17B10TP53RAB9ASMN1; SMN2 | |
| SCHEMBL4192484 | 0.76 | NPC1 (0.60) | NPC1HSD17B10TP53RAB9ASMN1; SMN2 | |
| SCHEMBL8890076 | 0.76 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8891692 | 0.76 | PDE4D (0.52) | PDE4DNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL8889395 | 0.75 | PDE4D (0.65) | PDE4DNPC1RAB9APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |