Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 4/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.46 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.45 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.42 |
| ▸ | TUBB | P07437 | 2/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879272 | 0.91 | KMT2A (0.57) | KMT2ASMN1; SMN2KDM4EPDGFRBPDGFRA | |
| SCHEMBL8879268 | 0.91 | KMT2A (0.57) | KMT2ASMN1; SMN2KDM4EPDGFRBPDGFRA | |
| SCHEMBL8889043 | 0.79 | RELA (0.47) | KMT2ASMN1; SMN2KDM4EPDGFRBPDGFRA | |
| SCHEMBL26791222 | 0.78 | KDM4E (0.60) | KMT2ASMN1; SMN2KDM4ENR1H4IP6K1 | |
| SCHEMBL30634278 | 0.78 | KDM4E (0.60) | KMT2ASMN1; SMN2KDM4ENR1H4IP6K1 | |
| SCHEMBL8501472 | 0.78 | PDGFRB (0.57) | KMT2ASMN1; SMN2KDM4EPDGFRBPDGFRA | |
| SCHEMBL8890227 | 0.77 | PDGFRB (0.48) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8890238 | 0.77 | PDGFRB (0.48) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL1431915 | 0.76 | KMT2A (0.58) | KMT2ASMN1; SMN2RELANR1H4NPC1 | |
| SCHEMBL31318867 | 0.76 | KMT2A (0.58) | KMT2ASMN1; SMN2RELANR1H4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |