Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | XPO1 | O14980 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879272 | 0.81 | KMT2A (0.57) | RELAKDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL8879268 | 0.81 | KMT2A (0.57) | RELAKDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL8890230 | 0.79 | KMT2A (0.54) | RELAKDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL8499635 | 0.77 | AXL (0.49) | PDGFRBPDGFRAMAP4K4GSK3AGSK3B | |
| SCHEMBL8889052 | 0.77 | MAP4K4 (0.42) | RELAPDGFRBPDGFRAMAP4K4GSK3A | |
| SCHEMBL8889037 | 0.77 | MAP4K4 (0.42) | RELAPDGFRBPDGFRAMAP4K4GSK3A | |
| SCHEMBL8887518 | 0.76 | NFE2L2 (0.47) | PDGFRBPDGFRAMAP4K4PIK3CAMTOR | |
| SCHEMBL8501972 | 0.76 | NFE2L2 (0.47) | PDGFRBPDGFRAMAP4K4PIK3CAMTOR | |
| SCHEMBL8889861 | 0.72 | MAP4K4 (0.45) | PDGFRBPDGFRAMAP4K4GSK3AGSK3B | |
| Hydrochloric Acid SCHEMBL8503257 | 0.72 | MTNR1B (0.46) | PDGFRBPDGFRAMAP4K4GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |