Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891047 | 0.89 | SYK (0.62) | SYKAURKBINCENPMAPTHDAC1 | |
| SCHEMBL8892307 | 0.89 | KDM4E (0.52) | SYKAURKBINCENPMAPTMEN1 | |
| SCHEMBL4319936 | 0.87 | SYK (0.56) | SYKAURKBINCENPMAPTHDAC1 | |
| SCHEMBL31691389 | 0.83 | KMT2A (0.47) | SYKAURKBINCENPMAPTMEN1 | |
| SCHEMBL2188210 | 0.82 | SMPD1 (0.76) | MAPTHDAC1SMPD1HDAC8HDAC6 | |
| SCHEMBL17835555 | 0.81 | MAPT (0.57) | SYKMAPTMEN1CYP1A2CYP2C19 | |
| SCHEMBL30320388 | 0.81 | PARP10 (0.69) | SYKAURKBINCENPMAPTPARP10 | |
| SCHEMBL1732629 | 0.81 | PARP10 (0.69) | SYKAURKBINCENPMAPTPARP10 | |
| SCHEMBL8891644 | 0.80 | MAPT (0.60) | MAPTHDAC1SMPD1HDAC8HDAC6 | |
| SCHEMBL8890013 | 0.80 | KDM4E (0.61) | SYKAURKBINCENPMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |