Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554925 | 0.82 | GPBAR1 (0.61) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL8555246 | 0.82 | GPBAR1 (0.61) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL8555104 | 0.81 | GPBAR1 (0.60) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL8555687 | 0.81 | GPBAR1 (0.60) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL9582699 | 0.74 | GPBAR1 (0.63) | GPBAR1CYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL15641608 | 0.73 | ALOX5 (0.70) | ALOX5HDAC6 | |
| SCHEMBL8834234 | 0.72 | GPBAR1 (0.57) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL7593150 | 0.72 | GPBAR1 (0.56) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| Hydrochloric Acid SCHEMBL9688324 | 0.71 | CYSLTR1 (0.52) | GPBAR1CYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL25435433 | 0.71 | GPBAR1 (0.56) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012866-A1 | BIS-HETEROARYLYLMETHOXYPHENYLKETONE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | disclosed |