Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645269 | 0.86 | SLC2A1 (0.33) | PTGS2MEN1KMT2A | |
| SCHEMBL8891216 | 0.85 | PTGS2 (0.37) | PTGS2PDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL8892354 | 0.85 | PTGS2 (0.36) | PTGS2PDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL8902224 | 0.82 | PTGS2 (0.36) | PTGS2PDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL8893019 | 0.81 | PTGS2 (0.35) | PTGS2PDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL8891536 | 0.80 | PTGS2 (0.34) | PTGS2PDE3BPDE3AALDH1A1SMN1; SMN2 | |
| SCHEMBL8671630 | 0.78 | PTGS2 (0.42) | PTGS2PDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL8893093 | 0.76 | PTGS2 (0.35) | PTGS2PDE3BPDE3AGAAALDH1A1 | |
| SCHEMBL8892692 | 0.76 | PTGS2 (0.35) | PTGS2PDE3BPDE3AMAPTSMN1; SMN2 | |
| SCHEMBL8645270 | 0.76 | KRAS (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997041100-A1 | IMINOXY DERIVATIVES OF INDOLE AND INDENE COMPOUNDS AS INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-11-06 | — | — | WO | claimed |
| WO-1997041100-A1 | IMINOXY DERIVATIVES OF INDOLE AND INDENE COMPOUNDS AS INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-11-06 | — | — | WO | disclosed |