Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.49 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8897789 | 0.83 | NPY5R (0.66) | BRAFRAF1EGLN1LMNACYP1A2 | |
| SCHEMBL2257238 | 0.80 | NPY5R (0.66) | MAPK1MEN1KMT2AABCG2CLK4 | |
| SCHEMBL30960995 | 0.80 | NPY5R (0.66) | MAPK1MEN1KMT2AABCG2CLK4 | |
| SCHEMBL6039347 | 0.78 | EGFR (0.65) | BRAFLMNACYP1A2CYP3A4MAPK1 | |
| SCHEMBL8899763 | 0.77 | KDM4E (0.50) | LMNACYP1A2MEN1KMT2ATRIM58 | |
| SCHEMBL15051337 | 0.77 | BRAF (0.84) | BRAFRAF1LMNACYP1A2CYP3A4 | |
| SCHEMBL8898615 | 0.76 | ABCG2 (0.71) | KMT2AABCG2 | |
| SCHEMBL19639039 | 0.76 | KDM4E (0.71) | LMNAMAPK1MEN1KMT2ATRIM58 | |
| SCHEMBL17367223 | 0.76 | KDM4E (0.71) | LMNAMAPK1MEN1KMT2ATRIM58 | |
| SCHEMBL29992999 | 0.76 | KDM4E (0.71) | LMNAMAPK1MEN1KMT2ATRIM58 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020822-A1 | QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |