Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 15/20 | 0.65 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14553152 | 0.81 | DHODH (0.95) | DHODHPLA2G2A | |
| SCHEMBL6037322 | 0.76 | DHODH (0.89) | DHODH | |
| SCHEMBL28958053 | 0.75 | PLA2G2A (0.57) | DHODHPLA2G2ACASP3 | |
| SCHEMBL30690080 | 0.75 | DHODH (0.54) | DHODHPLA2G2A | |
| SCHEMBL26606893 | 0.74 | TSHR (0.49) | DHODHPLA2G2A | |
| SCHEMBL1694669 | 0.74 | DHODH (0.50) | DHODHPLA2G2A | |
| SCHEMBL2461722 | 0.74 | DHODH (0.73) | DHODH | |
| SCHEMBL5815129 | 0.73 | KDM4E (0.64) | DHODHPLA2G2A | |
| SCHEMBL1695154 | 0.73 | PLA2G2A (0.54) | DHODHPLA2G2ACASP3 | |
| SCHEMBL1694671 | 0.73 | PLA2G2A (0.51) | DHODHPLA2G2ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997006144-A1 | 2-CARBOCYCLIC AND 2-HETEROCYCLIC QUINOLINE-4-CARBOXYLIC ACIDS AND SALTS THEREOF USEFUL AS IMMUNOSUPPRESSIVE AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-02-20 | — | — | WO | disclosed |
| US-5578609-A | INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE, ANTITUMOR, TREATMENT OF ORGAN REJECTION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| US-5523408-A | USED FOR TREATMENT OR PREVENTION OF ORGAN TRANSPLANT REJECTION, GRAFT VERSUS HOST DISEASE, CHRONIC INFLAMMATORY DISEASES LIKE PSORIASIS, RHEUMATOID ARTHRITIS IN MAMMAL | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-06-04 | — | — | US | disclosed |