Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.51 |
| ▸ | DHODH | Q02127 | 7/20 | 0.49 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694790 | 0.88 | PLA2G2A (0.51) | PLA2G2ADHODHTACR3CASP3KDM4E | |
| SCHEMBL1695154 | 0.87 | PLA2G2A (0.54) | PLA2G2ADHODHTACR3CASP3KDM4E | |
| SCHEMBL2717114 | 0.83 | DHODH (0.57) | PLA2G2ADHODHTACR3CASP3PRNP | |
| SCHEMBL1694918 | 0.78 | DHODH (0.39) | PLA2G2ADHODHTACR3CASP3KDM4E | |
| SCHEMBL1694669 | 0.78 | DHODH (0.50) | PLA2G2ADHODHTACR3KDM4EALDH1A1 | |
| SCHEMBL1695295 | 0.77 | PIK3CD (0.49) | — | |
| SCHEMBL1694789 | 0.75 | DHODH (0.50) | PLA2G2ADHODHTACR3ALDH1A1 | |
| SCHEMBL2719787 | 0.74 | DHODH (0.46) | PLA2G2ADHODHTACR3KDM4EPRNP | |
| SCHEMBL8890970 | 0.73 | DHODH (0.65) | PLA2G2ADHODHCASP3 | |
| SCHEMBL2716715 | 0.72 | DHODH (0.60) | PLA2G2ADHODHTACR3CASP3PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588467-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |