SCHEMBL8891215

SCHEMBL8891215

Cc1nc(C#N)c(SCCc2ccccc2)o1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.44
MAOB P27338 2/20 0.44
ALDH1A1 P00352 7/20 0.42
GAA P10253 6/20 0.42
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TSHR P16473 2/20 0.41
LMNA P02545 2/20 0.41
NPC1 O15118 1/20 0.41
PKM P14618 1/20 0.41
HTT P42858 1/20 0.41
MAPT P10636 7/20 0.41
GSK3B P49841 1/20 0.38
HPGD P15428 5/20 0.38
KDM4E B2RXH2 4/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
HSD17B10 Q99714 2/20 0.38
MAPK1 P28482 2/20 0.38
TP53 P04637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8893294 0.93 AR (0.39) MAOAMAOBALDH1A1GAARAB9A
SCHEMBL8890049 0.69 GAA (0.41) ALDH1A1GAARAB9ASMN1; SMN2TSHR
SCHEMBL3826613 0.69 ALDH1A1 (0.42) ALDH1A1GAARAB9ASMN1; SMN2TSHR
SCHEMBL8891161 0.65 HTT (0.46) ALDH1A1GAARAB9ASMN1; SMN2TSHR
SCHEMBL2960610 0.64 MAOA (0.49) MAOAMAOBALDH1A1GAACYP1A2
SCHEMBL13752161 0.63 ABCB1 (0.62) MAOAMAOBALDH1A1GAARAB9A
SCHEMBL22784147 0.62 MAOB (0.70) MAOAMAOBALDH1A1GAARAB9A
SCHEMBL20261927 0.62 ALDH1A1 (0.55) MAOAMAOBALDH1A1SMN1; SMN2TSHR
SCHEMBL12179246 0.60
Acetonitrile SCHEMBL28305683 0.60 MAOB (0.56) MAOAMAOBALDH1A1SMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997024340-A1 OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-07-10 WO disclosed