Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.75 |
| ▸ | DRD3 | P35462 | 2/20 | 0.75 |
| ▸ | DRD4 | P21917 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 5/20 | 0.74 |
| ▸ | HTR1D | P28221 | 2/20 | 0.74 |
| ▸ | HTR1B | P28222 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | HTR7 | P34969 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2218622 | 0.95 | DRD2 (0.82) | DRD2DRD3DRD4HTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL9355015 | 0.94 | DRD2 (0.81) | DRD2DRD3DRD4HTR1AHTR1D | |
| SCHEMBL8893091 | 0.90 | DRD2 (0.74) | DRD2DRD3DRD4HTR1AHTR1D | |
| SCHEMBL9558117 | 0.86 | DRD2 (0.70) | DRD2DRD3DRD4HTR1AHTR1D | |
| SCHEMBL2020108 | 0.86 | DRD2 (0.69) | DRD2DRD3DRD4HTR1AHTR1D | |
| SCHEMBL11388217 | 0.86 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR7 | |
| SCHEMBL12640568 | 0.85 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL9359305 | 0.85 | DRD2 (0.97) | DRD2DRD3DRD4HTR1AHTR7 | |
| SCHEMBL8925229 | 0.84 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AHTR1D | |
| SCHEMBL3732774 | 0.84 | DRD2 (0.85) | DRD2DRD3DRD4HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |