Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891559 | 1.00 | MAPT (0.39) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL7826308 | 0.95 | MAPT (0.42) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL7826311 | 0.95 | MAPT (0.42) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL7824380 | 0.82 | MEN1 (0.42) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL7824378 | 0.82 | MEN1 (0.42) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL7827129 | 0.78 | ATM (0.34) | MAPTALDH1A1CYP3A4 | |
| SCHEMBL27379002 | 0.77 | ALDH1A1 (0.38) | MAPTLMNAALDH1A1HCAR2CA1 | |
| SCHEMBL8481696 | 0.72 | MAPT (0.47) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL2003282 | 0.72 | MAPT (0.48) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL2003283 | 0.72 | MAPT (0.48) | MAPTLMNAMDM2MDM4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997024325-A1 | DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |