Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.67 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889710 | 0.84 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8891655 | 0.83 | PDE4B (0.70) | PDE4DF10PDE4APDE4BPDE4C | |
| SCHEMBL1026961 | 0.82 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434447 | 0.82 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8891275 | 0.81 | F10 (0.52) | PDE4DF10PDE4APDE4BPDE4C | |
| SCHEMBL8890013 | 0.80 | KDM4E (0.61) | PDE4DF10PDE4APDE4BPDE4C | |
| SCHEMBL8554187 | 0.80 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8892307 | 0.79 | KDM4E (0.52) | F10 | |
| SCHEMBL9279916 | 0.77 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890380 | 0.77 | PDE4D (0.41) | PDE4DF10PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |