Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.41 |
| ▸ | PDE4A | P27815 | 8/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890455 | 0.82 | ALDH1A1 (0.39) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL8890376 | 0.80 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8891956 | 0.80 | HPGD (0.40) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL8891595 | 0.77 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL8890126 | 0.74 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL8891655 | 0.72 | PDE4B (0.70) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL6583680 | 0.70 | PDE4B (0.42) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL19415860 | 0.69 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CALOX15 | |
| SCHEMBL8891135 | 0.69 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CF10 | |
| SCHEMBL7360805 | 0.68 | PDE4B (0.42) | PDE4DPDE4APDE4BPDE4CHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |