Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.47 |
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890145 | 0.79 | PDE4D (0.61) | KDM4EGAAALDH1A1PDE4DPDE4A | |
| SCHEMBL8892009 | 0.77 | PDE4D (0.55) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8891655 | 0.77 | PDE4B (0.70) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8888975 | 0.74 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL4662144 | 0.74 | KDM4E (0.54) | KDM4EGAAALDH1A1HSD11B1MAPT | |
| SCHEMBL3237987 | 0.73 | TYK2 (0.60) | PDE4DPDE4APDE4BPDE4CTYK2 | |
| SCHEMBL4037514 | 0.72 | PDE4D (0.56) | GAAPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8891135 | 0.71 | PDE4D (0.52) | KDM4EPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8891532 | 0.70 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL9128209 | 0.69 | CYP1A2 (0.56) | KDM4EGAAALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |