Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371258 | 1.00 | MAPT (0.58) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL17067577 | 0.88 | MAPT (0.60) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL2252810 | 0.86 | MAPT (0.58) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL12492178 | 0.85 | CREBBP (0.51) | MAPTKMT2AALDH1A1CA1CA2 | |
| SCHEMBL854310 | 0.85 | MAPT (0.57) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL30036339 | 0.85 | MAPT (0.57) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL29607431 | 0.85 | MAPT (0.57) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL17083282 | 0.85 | MAPT (0.57) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL31371201 | 0.85 | MAPT (0.57) | MAPTHIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL1020427 | 0.85 | MAPT (0.57) | MAPTHIF1AKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025001407-A1 | POLYARYL-CONTAINING MACROCYCLIC COMPOUNDS AND USES THEREOF | 浙江养生堂天然药物研究所有限公司 | 2025-01-02 | — | — | WO | disclosed |
| EP-3137470-B1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2021-04-07 | — | — | EP | disclosed |
| EP-3137470-B1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2021-04-07 | — | — | EP | disclosed |
| CN-106232603-B | Compound and composition as 7 agonist of TOLL- sample receptor | 诺华股份有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-105884699-B | 4- substituted aniline quinazoline derivative and its preparation method and application | 中国药科大学 | 2019-05-07 | — | — | CN | disclosed |
| US-9902730-B2 | Compounds and compositions as toll-like receptor 7 agonists | NOVARTIS AG (CH) | 2018-02-27 | — | — | US | disclosed |
| US-9902730-B2 | Compounds and compositions as toll-like receptor 7 agonists | NOVARTIS AG (CH) | 2018-02-27 | — | — | US | disclosed |
| CN-107207994-A | Photolabile acetal and ketal compounds for controlled release of active volatile carbonyl compounds | 弗门尼舍有限公司 | 2017-09-26 | — | — | CN | disclosed |
| EP-3137470-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | Novartis AG (CH) | 2017-03-08 | — | — | EP | disclosed |
| US-20170057968-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2017-03-02 | — | — | US | disclosed |
| CN-106232603-A | Compound and compositions as TOLL sample receptor 7 agonist | 诺华股份有限公司 | 2016-12-14 | — | — | CN | disclosed |
| WO-2015168269-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2015-11-05 | — | — | WO | disclosed |
| WO-2015168269-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | NOVARTIS AG (CH) | 2015-11-05 | — | — | WO | disclosed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057968-A1 | COMPOUNDS AND COMPOSITIONS AS TOLL-LIKE RECEPTOR 7 AGONISTS | TLR7, TLR3, TLR1 | MAPT 2368/4885HIF1A 2399/4885KMT2A 3997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.