Sugi Predict

Sugi Predict / Compounds / SCHEMBL854310

SCHEMBL854310

SCHEMBL854310

COC(=O)c1ccc(OC)c(CBr)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.57
▸ HIF1A Q16665 1/20 0.53
▸ KMT2A Q03164 4/20 0.51
▸ ALDH1A1 P00352 4/20 0.49
▸ MEN1 O00255 3/20 0.49
▸ CA1 P00915 2/20 0.47
▸ CA2 P00918 2/20 0.47
▸ CA12 O43570 1/20 0.47
▸ CA7 P43166 1/20 0.47
▸ XDH P47989 1/20 0.47
▸ CA9 Q16790 1/20 0.47
▸ CA14 Q9ULX7 1/20 0.47
▸ ATM Q13315 1/20 0.47
▸ TSHR P16473 3/20 0.46
▸ CYP2C9 P11712 4/20 0.46
▸ CYP1A2 P05177 3/20 0.46
▸ CYP3A4 P08684 3/20 0.46
▸ CYP2C19 P33261 3/20 0.46
▸ MGLL Q99685 1/20 0.46
▸ CYP2D6 P10635 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30036339 1.00 MAPT (0.57) MAPTHIF1AKMT2AALDH1A1MEN1
SCHEMBL6615672 0.87 MAPT (0.54) MAPTHIF1AKMT2AALDH1A1MEN1
SCHEMBL184552 0.87 MAPT (0.57) MAPTHIF1AKMT2AALDH1A1MEN1
SCHEMBL17067577 0.86 MAPT (0.60) MAPTHIF1AKMT2AALDH1A1MEN1
SCHEMBL5344735 0.86 HSD17B2 (0.61) MAPTKMT2AALDH1A1MEN1CA1
SCHEMBL21044158 0.86 RAB9A (0.49) MAPTHIF1AKMT2AALDH1A1CA1
SCHEMBL8900281 0.85 CA12 (0.62) KMT2AALDH1A1MEN1CA1CA2
SCHEMBL31371258 0.85 MAPT (0.58) MAPTHIF1AKMT2AALDH1A1MEN1
SCHEMBL8891941 0.85 MAPT (0.58) MAPTHIF1AKMT2AALDH1A1MEN1
SCHEMBL6616357 0.84 MAPT (0.51) MAPTHIF1AKMT2AALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121005621-A Preparation method of 3- (bromomethyl) -4-methoxybenzoic acid methyl ester 安徽硕源医药技术研发有限公司 2025-11-25 — — CN disclosed
CN-121005621-A Preparation method of 3- (bromomethyl) -4-methoxybenzoic acid methyl ester 安徽硕源医药技术研发有限公司 2025-11-25 — — CN disclosed
US-20250282786-A1 Tricyclic TLR7 Agonists and Uses Thereof BRISTOL-MYERS SQUIBB COMPANY (US) 2025-09-11 — — US disclosed
WO-2025080049-A1 COMPOUND FOR INHIBITING ATX, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING ATX ACTIVITY-RELATED DISEASES CONTAINING SAME AS ACTIVE INGREDIENT 한국화학연구원 2025-04-17 — — WO disclosed
US-20250073236-A1 PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS APROS THERAPEUTICS INC (US) 2025-03-06 — — US disclosed
WO-2025001408-A1 PHOSPHORUS-CONTAINING OR SULFUR-CONTAINING MACROCYCLIC PYRAZOLOPYRIMIDINE COMPOUND AND USE THEREOF 浙江养生堂天然药物研究所有限公司 2025-01-02 — — WO disclosed
WO-2024199069-A1 POLYARYL-CONTAINING MACROCYCLIC COMPOUND AND USE THEREOF 浙江养生堂天然药物研究所有限公司 2024-10-03 — — WO disclosed
WO-2024199063-A1 PHOSPHORUS OR SULFUR-CONTAINING MACROCYCLE AND USE THEREOF 浙江养生堂天然药物研究所有限公司 2024-10-03 — — WO disclosed
CN-111253404-B Nitrogen-containing heterocyclic compound and composition, preparation method and application thereof 上海医药集团股份有限公司 2023-05-23 — — CN disclosed
US-20230118688-A1 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS BRISTOL-MYERS SQUIBB COMPANY 2023-04-20 — — US disclosed
US-20070225303-A1 8-Oxoadenine Compound DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-09-27 — — US disclosed
WO-2007067478-A2 P38 KINASE INHIBITING AGENTS MERCK & CO., INC. (US) 2007-06-14 — — WO disclosed
WO-2007067478-A2 P38 KINASE INHIBITING AGENTS MERCK & CO., INC. (US) 2007-06-14 — — WO disclosed
US-20070129372-A1 P38 kinase inhibiting agents MERCK SHARP & DOHME CORP. 2007-06-07 — — US disclosed
US-20070129372-A1 P38 kinase inhibiting agents MERCK SHARP & DOHME CORP. 2007-06-07 — — US disclosed
US-20070129372-A1 P38 kinase inhibiting agents MERCK SHARP & DOHME CORP. 2007-06-07 — — US disclosed
EP-1784182-A1 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS Actelion Pharmaceuticals Ltd. (CH) 2007-05-16 — — EP disclosed
EP-1728792-A1 8-OXOADENINE COMPOUND Dainippon Sumitomo Pharma Co., Ltd. (JP) 2006-12-06 — — EP disclosed
WO-2006021418-A1 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2006-03-02 — — WO disclosed
WO-1997003967-A1 SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE RHONE-POULENC RORER LIMITED (GB) 1997-02-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282786-A1 Tricyclic TLR7 Agonists and Uses Thereof TLR7, TLR9, TLR1 MAPT 3686/4885HIF1A 3623/4885KMT2A 1868/4885
US-20070225303-A1 8-Oxoadenine Compound TLR7, CCR8, TLR8 MAPT 4054/4885HIF1A 595/4885KMT2A 825/4885
US-20250073236-A1 PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS MAVS, TLR7, STING1 MAPT 4286/4885HIF1A 2440/4885KMT2A 2768/4885
US-20230118688-A1 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS TLR7, TLR1, TLR9 MAPT 3546/4885HIF1A 2694/4885KMT2A 2496/4885
US-20070129372-A1 P38 kinase inhibiting agents MAPK1, MAPK8, MAPK7 MAPT 79/4885HIF1A 1464/4885KMT2A 4540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.