Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.76 |
| ▸ | PDE4A | P27815 | 12/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.76 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.58 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piclamilast SCHEMBL26573 | 0.86 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL70770 | 0.86 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7335911 | 0.85 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7336534 | 0.84 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7336538 | 0.84 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7341113 | 0.84 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7338639 | 0.84 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7335658 | 0.84 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7338627 | 0.84 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7354173 | 0.84 | PDE4D (0.83) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |