Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | NPY1R | P25929 | 1/20 | 0.56 |
| ▸ | NPY2R | P49146 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351217 | 0.85 | SIRT2 (0.73) | LMNAMAPTTSHRSIRT2NPC1 | |
| SCHEMBL24922866 | 0.81 | SIRT2 (0.47) | LMNAATMMAPTTSHRALDH1A1 | |
| SCHEMBL6325229 | 0.81 | LMNA (0.76) | LMNAATMMAPTTSHRALDH1A1 | |
| SCHEMBL8900040 | 0.80 | LMNA (0.66) | LMNAATMMAPTTSHRALDH1A1 | |
| SCHEMBL30689335 | 0.79 | LMNA (0.49) | LMNAATMMAPTTSHRSIRT2 | |
| SCHEMBL18105004 | 0.79 | LMNA (0.62) | LMNAATMMAPTTSHRALDH1A1 | |
| SCHEMBL1567346 | 0.78 | LMNA (1.00) | LMNAATMMAPTTSHRALDH1A1 | |
| SCHEMBL1313507 | 0.78 | SPHK1 (0.61) | SIRT2 | |
| SCHEMBL5717772 | 0.77 | LMNA (0.79) | LMNAATMMAPTALDH1A1MEN1 | |
| SCHEMBL17513948 | 0.77 | SIRT2 (0.65) | LMNAATMMAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |