SCHEMBL8900040

SCHEMBL8900040

COc1ccc(-c2noc(CO)n2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.66
ATM Q13315 1/20 0.66
SIRT2 Q8IXJ6 1/20 0.65
NOTUM Q6P988 2/20 0.64
L3MBTL1 Q9Y468 5/20 0.63
MAPT P10636 5/20 0.63
NPC1 O15118 4/20 0.63
RAB9A P51151 4/20 0.63
TDP1 Q9NUW8 3/20 0.62
TSHR P16473 3/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
KDM4E B2RXH2 2/20 0.62
HTT P42858 2/20 0.62
KMT2A Q03164 2/20 0.62
MEN1 O00255 1/20 0.62
ALOX15 P16050 1/20 0.62
MAPK1 P28482 1/20 0.62
CASP3 P42574 1/20 0.60
SENP8 Q96LD8 1/20 0.60
SENP7 Q9BQF6 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17513948 0.84 SIRT2 (0.65) LMNAATMSIRT2NOTUML3MBTL1
SCHEMBL1220782 0.84 SMN1; SMN2 (0.66) LMNAATMSIRT2L3MBTL1MAPT
SCHEMBL14788168 0.84 SIRT2 (0.74) LMNAATMSIRT2L3MBTL1MAPT
SCHEMBL7952282 0.83 SIRT2 (0.72) LMNAATMSIRT2L3MBTL1MAPT
SCHEMBL6325229 0.82 LMNA (0.76) LMNAATMSIRT2L3MBTL1MAPT
SCHEMBL6527881 0.81 NOTUM (0.70) LMNAATMNOTUML3MBTL1MAPT
SCHEMBL7148635 0.81 SIRT2 (0.70) LMNAATMSIRT2L3MBTL1MAPT
SCHEMBL27035148 0.81 ALDH1A1 (0.65) LMNAATMSIRT2L3MBTL1MAPT
SCHEMBL15133520 0.81 KMT2A (0.63) LMNAATMSIRT2L3MBTL1MAPT
SCHEMBL1567346 0.80 LMNA (1.00) LMNAATMSIRT2L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250091999-A1 [3-(4-METHOXYPHENYL)-1,2,4-OXADIAZOL-5-YL]METHANOL AS AN ANTITUMOR AND ANTIMICROBIAL COMPOUND UNIV KING FAISAL (SA) 2025-03-20 US claimed
US-12180172-B1 [3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methanol as an antitumor and antimicrobial compound King Faisal University (SA) 2024-12-31 US claimed
US-20250091999-A1 [3-(4-METHOXYPHENYL)-1,2,4-OXADIAZOL-5-YL]METHANOL AS AN ANTITUMOR AND ANTIMICROBIAL COMPOUND UNIV KING FAISAL (SA) 2025-03-20 US disclosed
US-20250091999-A1 [3-(4-METHOXYPHENYL)-1,2,4-OXADIAZOL-5-YL]METHANOL AS AN ANTITUMOR AND ANTIMICROBIAL COMPOUND UNIV KING FAISAL (SA) 2025-03-20 US disclosed
US-20250091999-A1 [3-(4-METHOXYPHENYL)-1,2,4-OXADIAZOL-5-YL]METHANOL AS AN ANTITUMOR AND ANTIMICROBIAL COMPOUND UNIV KING FAISAL (SA) 2025-03-20 US disclosed
US-12180172-B1 [3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methanol as an antitumor and antimicrobial compound King Faisal University (SA) 2024-12-31 US disclosed
US-12180172-B1 [3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methanol as an antitumor and antimicrobial compound King Faisal University (SA) 2024-12-31 US disclosed
US-12180172-B1 [3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methanol as an antitumor and antimicrobial compound King Faisal University (SA) 2024-12-31 US disclosed
WO-1997003967-A1 SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE RHONE-POULENC RORER LIMITED (GB) 1997-02-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250091999-A1 [3-(4-METHOXYPHENYL)-1,2,4-OXADIAZOL-5-YL]METHANOL AS AN ANTITUMOR AND ANTIMICROBIAL COMPOUND OXA1L, MCL1, CASP3 LMNA 4266/4885ATM 1674/4885SIRT2 1993/4885
US-12180172-B1 [3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methanol as an antitumor and antimicrobial compound OXA1L, MCL1, CASP3 LMNA 4266/4885ATM 1674/4885SIRT2 1993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.