Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041618 | 0.86 | CYP3A4 (0.47) | CYP3A4MAPTHPGDMEN1KMT2A | |
| SCHEMBL8889121 | 0.81 | CYSLTR2 (0.45) | CYP3A4FFAR1L3MBTL1USP2LMNA | |
| SCHEMBL8889127 | 0.81 | CYSLTR2 (0.45) | CYP3A4FFAR1L3MBTL1USP2LMNA | |
| SCHEMBL8464318 | 0.77 | MRGPRX4 (0.46) | HPGDSMN1; SMN2CYP19A1ALDH1A1MAOB | |
| SCHEMBL17385770 | 0.76 | MAOB (0.57) | HPGDSMN1; SMN2ALDH1A1LMNAMAOB | |
| SCHEMBL8889671 | 0.75 | MAOB (0.48) | MAPTHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL8889666 | 0.75 | MAOB (0.48) | MAPTHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL9520446 | 0.74 | CYSLTR1 (0.54) | — | |
| SCHEMBL8899706 | 0.74 | LTB4R (0.52) | CYP3A4FFAR1L3MBTL1USP2 | |
| SCHEMBL8899697 | 0.74 | LTB4R (0.52) | CYP3A4FFAR1L3MBTL1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |