Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC5 | O15392 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893532 | 0.87 | BIRC5 (0.53) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL10153905 | 0.76 | BIRC5 (0.64) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL5216431 | 0.75 | BIRC5 (0.55) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL28580892 | 0.75 | CDC7 (0.49) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL9377416 | 0.75 | CDK2 (0.42) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| Dimethylamine SCHEMBL5608192 | 0.73 | BIRC5 (0.61) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL9377830 | 0.72 | BIRC5 (0.42) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL13105711 | 0.72 | BIRC5 (0.61) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| Iodide SCHEMBL8894187 | 0.71 | BIRC5 (0.41) | BIRC5PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL4426563 | 0.70 | BIRC5 (0.67) | BIRC5PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654298-A | QUARTERNARY SALTS OF 4-AMINO-SUBSTITUTED PYRIDINES; MODULATORS OF THE SINOATRIAL NODE; CARDIOTONIC AND BRADYCARDIA AGENTS; | IMPERIAL CHEMICAL INDUSTRIES (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0453197-B1 | Amine derivatives | ICI PLC (GB) | 1994-06-15 | — | — | EP | disclosed |
| EP-0453197-A1 | Amine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-23 | — | — | EP | disclosed |