SCHEMBL8892822

SCHEMBL8892822

CCOC(=O)c1noc(C2CC2)c1C(=O)c1ccccc1Cc1ccccc1SCF

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.34
ALDH1A1 P00352 5/20 0.33
HCRTR2 O43614 2/20 0.33
TSHR P16473 5/20 0.32
KMT2A Q03164 3/20 0.32
NPSR1 Q6W5P4 3/20 0.32
MAPT P10636 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
NFKB1 P19838 1/20 0.32
CYP2C19 P33261 1/20 0.32
BLM P54132 1/20 0.32
PMP22 Q01453 1/20 0.32
HIF1A Q16665 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
ALOX15 P16050 1/20 0.32
MAPK1 P28482 1/20 0.32
MEN1 O00255 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8892752 0.90 ALDH1A1 (0.38) HTTALDH1A1HCRTR2TSHRKMT2A
SCHEMBL8891053 0.88 KMT2A (0.33) HTTALDH1A1HCRTR2TSHRKMT2A
SCHEMBL8890586 0.86 ALDH1A1 (0.37) HTTALDH1A1HCRTR2TSHRNPSR1
SCHEMBL8890880 0.86 SLC6A2 (0.41) HTTALDH1A1KMT2ANPSR1TDP1
SCHEMBL8890325 0.84 HTT (0.34) HTTALDH1A1HCRTR2TSHRNPSR1
SCHEMBL8890952 0.84 ALDH1A1 (0.33) HTTALDH1A1HCRTR2TSHRKMT2A
SCHEMBL8890654 0.83 HTT (0.34) HTTALDH1A1HCRTR2TSHRNPSR1
SCHEMBL8891083 0.83 HTT (0.40) HTTALDH1A1HCRTR2TSHRKMT2A
SCHEMBL8892409 0.83 HCRTR2 (0.34) HTTALDH1A1HCRTR2TSHRNPSR1
SCHEMBL8890606 0.83 HTT (0.37) HTTALDH1A1HCRTR2TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997028136-A1 BENZOYLISOXAZOLES AND 2-CYANO-1,3-DIONE DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1997-08-07 WO disclosed