SCHEMBL8892825

SCHEMBL8892825

Cc1cc(NCC(=O)O)cc(C)c1Oc1ccc(O)c(C(C)C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 9/20 0.73
THRB P10828 9/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8891570 0.87 THRA (0.74) THRATHRB
SCHEMBL8894466 0.87 THRA (0.71) THRATHRB
SCHEMBL8892696 0.87 THRB (0.61) THRATHRB
SCHEMBL4962611 0.85 THRA (1.00) THRATHRB
SCHEMBL12584183 0.83 THRA (1.00) THRATHRB
SCHEMBL8892880 0.83 THRA (0.72) THRATHRB
SCHEMBL281877 0.82 THRA (1.00) THRATHRB
SCHEMBL29373673 0.82 THRA (1.00) THRATHRB
SCHEMBL7073126 0.81 THRA (0.76) THRATHRB
SCHEMBL4210679 0.81 THRA (0.67) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5654468-A ANTILIPID, ANTICHOLESTEROL AGENTS CIBA-GEIGY CORPORATION (US) 1997-08-05 US disclosed
US-5569674-A ANTICHOLESTEROL AGENTS CIBA-GEIGY CORPORATION (US) 1996-10-29 US disclosed
US-5401772-A Anticholesterol agents with aromatic amines CIBA-GEIGY CORPORATION (US) 1995-03-28 US disclosed