Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | MMP15 | P51511 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892969 | 1.00 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1LTB4RLTB4R2CA2 | |
| SCHEMBL8890711 | 0.86 | LTB4R (0.40) | CYSLTR2CYSLTR1LTB4RLTB4R2CA2 | |
| SCHEMBL8890710 | 0.86 | LTB4R (0.40) | CYSLTR2CYSLTR1LTB4RLTB4R2CA2 | |
| SCHEMBL8898787 | 0.85 | CYSLTR1 (0.53) | CYSLTR2CYSLTR1LTB4RLTB4R2 | |
| SCHEMBL8898782 | 0.85 | CYSLTR1 (0.53) | CYSLTR2CYSLTR1LTB4RLTB4R2 | |
| SCHEMBL8898722 | 0.84 | CYSLTR1 (0.51) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL8898717 | 0.84 | CYSLTR1 (0.51) | CYSLTR2CYSLTR1LTB4R | |
| SCHEMBL8897252 | 0.84 | CYSLTR1 (0.59) | CYSLTR2CYSLTR1LTB4RLTB4R2 | |
| SCHEMBL8899272 | 0.84 | CYSLTR1 (0.49) | CYSLTR2CYSLTR1LTB4RLTB4R2 | |
| SCHEMBL8899267 | 0.84 | CYSLTR1 (0.49) | CYSLTR2CYSLTR1LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |