Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.35 |
| ▸ | STS | P08842 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890711 | 1.00 | LTB4R (0.40) | LTB4RLTB4R2ESR1ESR2CYSLTR2 | |
| SCHEMBL8892971 | 0.86 | CYSLTR2 (0.45) | LTB4RLTB4R2CYSLTR2CYSLTR1CA2 | |
| SCHEMBL8892969 | 0.86 | CYSLTR2 (0.45) | LTB4RLTB4R2CYSLTR2CYSLTR1CA2 | |
| SCHEMBL8889605 | 0.82 | LTB4R (0.54) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL8890267 | 0.80 | CYP19A1 (0.50) | ESR1ESR2CA2KDM1APTGS1 | |
| SCHEMBL8898782 | 0.79 | CYSLTR1 (0.53) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL8898787 | 0.79 | CYSLTR1 (0.53) | LTB4RLTB4R2CYSLTR2CYSLTR1 | |
| SCHEMBL8890954 | 0.78 | CYP19A1 (0.53) | ESR1ESR2CA2CYP3A4 | |
| SCHEMBL8898717 | 0.78 | CYSLTR1 (0.51) | LTB4RCYSLTR2CYSLTR1 | |
| SCHEMBL8898722 | 0.78 | CYSLTR1 (0.51) | LTB4RCYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |