Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571016 | 0.82 | CYP19A1 (0.46) | CYP19A1SLC6A4SLC6A3TBXAS1 | |
| SCHEMBL8892342 | 0.80 | CYP19A1 (0.68) | CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL8892780 | 0.80 | SIGMAR1 (0.55) | SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL7564058 | 0.79 | CYP19A1 (0.45) | CYP19A1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL7570978 | 0.79 | CYP19A1 (0.45) | CYP19A1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8798224 | 0.77 | CYP19A1 (0.64) | CYP19A1TBXAS1 | |
| SCHEMBL11633201 | 0.75 | CYP19A1 (0.73) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8934782 | 0.74 | CYP19A1 (0.68) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11631856 | 0.73 | CYP19A1 (0.67) | CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL8684902 | 0.73 | QPCT (0.73) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997027175-A1 | SUBSTITUTED ETHYL α,α - DIARYLMETHYL ETHER DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1997-07-31 | — | — | WO | claimed |
| WO-1997027175-A1 | SUBSTITUTED ETHYL α,α - DIARYLMETHYL ETHER DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1997-07-31 | — | — | WO | disclosed |