Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Gamma-Tocopherol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.80 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.80 |
| ▸ | PHLPP1 | O60346 | 3/20 | 0.80 |
| ▸ | ILK | Q13418 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.59 |
| ▸ | TTPA | P49638 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gamma-Tocopherol SCHEMBL8894990 | 0.99 | AKT1 (0.82) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL27730430 | 0.99 | AKT1 (0.82) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL8652038 | 0.99 | AKT1 (0.82) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL8408124 | 0.94 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL16430717 | 0.94 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL39640 | 0.94 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| SCHEMBL15441242 | 0.94 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL17874900 | 0.94 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL29620131 | 0.94 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA | |
| Gamma-Tocopherol SCHEMBL29373100 | 0.94 | AKT1 (0.91) | AKT1PDPK1PHLPP1ILKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643597-A | FREE RADICAL SCAVENGERS | LVMH RECHERCHE (FR) | 1997-07-01 | — | — | US | disclosed |
| US-5603949-A | ANTIALLERGENS; SKIN DISORDERS | LVMH RECHERCHE (FR) | 1997-02-18 | — | — | US | disclosed |