Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.79 |
| ▸ | HTR7 | P34969 | 3/20 | 0.79 |
| ▸ | DRD2 | P14416 | 2/20 | 0.79 |
| ▸ | HTR1D | P28221 | 2/20 | 0.79 |
| ▸ | DRD3 | P35462 | 2/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | HTR1B | P28222 | 1/20 | 0.79 |
| ▸ | HTR2A | P28223 | 1/20 | 0.79 |
| ▸ | HTR2C | P28335 | 1/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.79 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.79 |
| ▸ | HTR2B | P41595 | 1/20 | 0.79 |
| ▸ | HTR5A | P47898 | 1/20 | 0.79 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891873 | 0.92 | HTR1A (0.90) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL29389900 | 0.88 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL29565039 | 0.88 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL1682347 | 0.88 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL496783 | 0.88 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL1682330 | 0.88 | HTR1A (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL1682286 | 0.87 | BLM (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL1682308 | 0.87 | BLM (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| 8-Oh-Dpat SCHEMBL1682320 | 0.87 | BLM (1.00) | HTR1AHTR7DRD2HTR1DDRD3 | |
| SCHEMBL3806268 | 0.85 | HTR1A (0.62) | HTR1AHTR7DRD2HTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |