Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.59 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922918 | 0.90 | ALOX5 (0.57) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8892196 | 0.89 | CYSLTR2 (0.50) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8922598 | 0.88 | ALOX5 (0.46) | ALOX5ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8922287 | 0.82 | CYSLTR2 (0.64) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8925370 | 0.81 | CYSLTR2 (0.63) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8922290 | 0.81 | ALOX5AP (0.53) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8925365 | 0.81 | ALOX5AP (0.53) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8908571 | 0.80 | ALOX5AP (0.56) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8922323 | 0.80 | ALOX5AP (0.58) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 | |
| SCHEMBL8920223 | 0.79 | CYSLTR2 (0.62) | ALOX5GPBAR1ALOX5APCYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997029090-A1 | BIS-(HETEROARYLMETHOXYPHENYL)CYCLOALKYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF LEUKOTRIENE BIOSYTHESIS | ABBOTT LABORATORIES (US) | 1997-08-14 | — | — | WO | claimed |
| US-5691351-A | Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1997-11-25 | — | — | US | disclosed |