Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 7/20 | 0.41 |
| ▸ | RARB | P10826 | 7/20 | 0.41 |
| ▸ | RARG | P13631 | 4/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893996 | 1.00 | RARA (0.41) | RARARARBRARGSIRT2SLC6A2 | |
| SCHEMBL6294019 | 0.86 | RARA (0.42) | RARARARBRARGSIRT2SLC6A2 | |
| SCHEMBL6294064 | 0.81 | RARA (0.48) | RARARARBRARGSLC6A2SLC6A4 | |
| SCHEMBL6297467 | 0.81 | RARA (0.43) | RARARARBRARGSLC6A2SLC6A4 | |
| SCHEMBL6292706 | 0.79 | RARA (0.46) | RARARARBRARGSLC6A2SLC6A4 | |
| SCHEMBL10959462 | 0.75 | RARA (0.68) | RARARARBRARG | |
| SCHEMBL6294335 | 0.70 | RARA (0.48) | RARARARBRARGSLC6A2SLC6A4 | |
| SCHEMBL9047784 | 0.69 | RARB (0.67) | RARARARBRARG | |
| SCHEMBL6292635 | 0.67 | RARA (0.62) | RARARARBRARGSLC6A2SLC6A3 | |
| SCHEMBL8669545 | 0.66 | RARB (0.49) | RARARARBRARGFDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |