Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.58 |
| ▸ | TXNRD3 | Q86VQ6 | 2/20 | 0.58 |
| ▸ | TXNRD2 | Q9NNW7 | 2/20 | 0.58 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | POR | P16435 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893539 | 0.75 | TOP1 (0.53) | TXNRD1TXNRD3TXNRD2TOP1IDO1 | |
| SCHEMBL30003440 | 0.65 | TOP1 (1.00) | TXNRD1TXNRD3TXNRD2TOP1IDO1 | |
| SCHEMBL29018326 | 0.65 | TOP1 (0.67) | TOP1IDO1CA1CA2CA7 | |
| SCHEMBL3414850 | 0.65 | TOP1 (1.00) | TXNRD1TXNRD3TXNRD2TOP1IDO1 | |
| SCHEMBL30882513 | 0.65 | CA1 (0.44) | TOP1IDO1CA1CA2CA7 | |
| SCHEMBL12896658 | 0.62 | RET (0.54) | TOP1CA1CA2CA7CA9 | |
| SCHEMBL384815 | 0.60 | TOP1 (0.55) | TOP1CA1CA2CA7CA9 | |
| SCHEMBL29378366 | 0.60 | TOP1 (0.55) | TOP1CA1CA2CA7CA9 | |
| SCHEMBL15613862 | 0.59 | TXNRD1 (0.44) | TXNRD1TXNRD3TXNRD2MAPTHPGD | |
| SCHEMBL768807 | 0.59 | MAPT (0.55) | TOP1ACHEALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594158-A | Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1997-01-14 | — | — | US | disclosed |
| US-5200513-A | Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin | BOARD OF REGENTS, UNIVERSITY OF NEBRASKA-LINCOLN (US) | 1993-04-06 | — | — | US | disclosed |
| EP-0523289-A1 | Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin | Board of Regents of the University of Nebraska (US) | 1993-01-20 | — | — | EP | disclosed |