Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CDC25B | P30305 | 2/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30003440 | 1.00 | TOP1 (1.00) | TOP1ALDH1A1MAPTAPAF1MITF | |
| SCHEMBL29018326 | 0.80 | TOP1 (0.67) | TOP1ALDH1A1MAPTAPAF1MITF | |
| SCHEMBL24194098 | 0.79 | TOP1 (0.66) | TOP1ALDH1A1MAPTAPAF1LMNA | |
| SCHEMBL30574283 | 0.79 | TOP1 (0.66) | TOP1ALDH1A1MAPTAPAF1LMNA | |
| SCHEMBL29442957 | 0.78 | TOP1 (0.63) | TOP1ALDH1A1MAPTAPAF1MITF | |
| SCHEMBL358094 | 0.78 | TOP1 (0.63) | TOP1ALDH1A1MAPTAPAF1MITF | |
| SCHEMBL1287104 | 0.78 | TOP1 (0.65) | TOP1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL24194431 | 0.78 | TOP1 (0.64) | TOP1ALDH1A1MAPTAPAF1MITF | |
| SCHEMBL3417492 | 0.77 | EGFR (0.76) | TOP1ALDH1A1MAPTAPAF1MITF | |
| SCHEMBL28575370 | 0.77 | MEN1 (0.72) | TOP1ALDH1A1MAPTAPAF1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113368087-A | Juglone derivatives and application thereof in preparation of drugs for treating brain tumors through chemotherapy | 复旦大学附属华山医院 | 2021-09-10 | — | — | CN | claimed |
| EP-0876356-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA Société Anonyme (FR) | 1998-11-11 | — | — | EP | claimed |
| WO-1997021684-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA, SOCIETE ANONYME (FR) | 1997-06-19 | — | — | WO | claimed |
| CN-109553756-B | Method for producing phosphorus-containing epoxy resin | 日铁化学材料株式会社 | 2023-09-29 | — | — | CN | disclosed |
| US-11613509-B2 | Radical polymerization control agent and radical polymerization control method | KAWASAKI KASEI CHEMICALS LTD. (JP) | 2023-03-28 | — | — | US | disclosed |
| CN-110891980-B | Radical polymerization control agent and radical polymerization control method | 川崎化成工业株式会社 | 2022-09-30 | — | — | CN | disclosed |
| WO-2022050774-A1 | NOVEL IMIDAZOLE DERIVATIVE SALT HAVING ANTIFUNGAL ACTIVITY, AND USE THEREOF | 경희대학교 산학협력단 | 2022-03-10 | — | — | WO | disclosed |
| CN-113368087-A | Juglone derivatives and application thereof in preparation of drugs for treating brain tumors through chemotherapy | 复旦大学附属华山医院 | 2021-09-10 | — | — | CN | disclosed |
| US-20210122692-A1 | RADICAL POLYMERIZATION CONTROL AGENT AND RADICAL POLYMERIZATION CONTROL METHOD | KAWASAKI KASEI CHEMICALS LTD. (JP) | 2021-04-29 | — | — | US | disclosed |
| US-10927085-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | HUEN CO., LTD. (KR) | 2021-02-23 | — | — | US | disclosed |
| US-10927085-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | HUEN CO., LTD. (KR) | 2021-02-23 | — | — | US | disclosed |
| WO-2008008033-A1 | THE USE OF NAPHTOQUINONES IN THE TREATMENT AND CONTROL OF DIABETES, INSULIN RESISTANCE AND HYPERGLYCEMIA | GLUCOX BIOTECH AB (SE) | 2008-01-17 | — | — | WO | disclosed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |
| EP-0876356-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA Société Anonyme (FR) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997021684-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA, SOCIETE ANONYME (FR) | 1997-06-19 | — | — | WO | disclosed |
| EP-0161102-B1 | ISOQUINOLINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-02-21 | — | — | EP | disclosed |
| US-4835158-A | Isoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1989-05-30 | — | — | US | disclosed |
| EP-0161102-A2 | Isoquinoline derivatives | GLAXO GROUP LIMITED (GB) | 1985-11-13 | — | — | EP | disclosed |
| US-4419439-A | ALKOXYNAPHTHOL DEVELOPER | FUJI PHOTO FILM CO., LTD. (JP) | 1983-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11613509-B2 | Radical polymerization control agent and radical polymerization control method | PPOX, NOX4, CROCC | TOP1 4499/4885ALDH1A1 1023/4885MAPT 188/4885 |
| US-20210122692-A1 | RADICAL POLYMERIZATION CONTROL AGENT AND RADICAL POLYMERIZATION CONTROL METHOD | PPOX, NOX4, CROCC | TOP1 4499/4885ALDH1A1 1023/4885MAPT 188/4885 |
| US-10927085-B2 | 1,2-naphthoquinone based derivative and method of preparing the same | UGT1A6, CYP2D6, SLC5A1 | TOP1 353/4885ALDH1A1 521/4885MAPT 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.