Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.72 |
| ▸ | RXRG | P48443 | 5/20 | 0.72 |
| ▸ | RXRB | P28702 | 4/20 | 0.72 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.49 |
| ▸ | RARA | P10276 | 5/20 | 0.47 |
| ▸ | RARB | P10826 | 5/20 | 0.47 |
| ▸ | RARG | P13631 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013234 | 0.85 | CYP26B1 (0.58) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL8894039 | 0.84 | RXRA (1.00) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL6890269 | 0.77 | RXRA (0.70) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL9551743 | 0.77 | RARA (0.74) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL3819796 | 0.76 | RARB (0.60) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL9417503 | 0.76 | KMT2A (0.66) | GAAKMT2ACYP2C9HPGDRECQL | |
| SCHEMBL16874512 | 0.75 | CYP26B1 (0.52) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL6032979 | 0.75 | RARA (0.48) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL6887779 | 0.75 | RXRA (0.71) | RXRARXRGRXRBCYP26A1RARA | |
| SCHEMBL8015924 | 0.75 | RXRA (0.71) | RXRARXRGRXRBCYP26A1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997016422-A1 | SULFIDES, SULFOXIDES AND SULFONES DISUBSTITUTED WITH A TETRAHYDRONAPHTHALENYL, CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL AND SUBSTITUTED PHENYL OR HETEROARYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-09 | — | — | WO | claimed |
| US-5672710-A | SPECIFIC AGONISTS FOR THE RXR RETINOID RECEPTOR RATHER THAN THE RAR ONE; SIDE EFFECT REDUCTION; SKIN AND NERVOUS SYTEM DISORDERS; ANTICARCINOGENIC AGENTS; VISION DEFECTS | ALLERGAN (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1997016422-A1 | SULFIDES, SULFOXIDES AND SULFONES DISUBSTITUTED WITH A TETRAHYDRONAPHTHALENYL, CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL AND SUBSTITUTED PHENYL OR HETEROARYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-09 | — | — | WO | disclosed |